i tried posting this

Obese individuals show increased risk factors for severe infections and significant immune system dysregulation that may impair the immune response to vaccines.

The reduced immune response of obese patients to vaccination can be deleterious not only for the patient but also for the community.

https://academic.oup.com/jid/article/205/2/172/2192687

If obesity impairs the immune response to influenza vaccination, then a highly vulnerable population will not be fully protected. Indeed, several studies show that the response to hepatitis or tetanus vaccination may be suboptimal in obese individuals

The possibility that influenza vaccination is not fully protective in obese humans has significant implications for public health. The growing global obesity epidemic and the constant threat of an influenza pandemic necessitate that obesity should be regarded as an independent risk factor, much like advanced age, and that current vaccine strategies may need to be adjusted for this population

https://www.tandfonline.com/doi/full/10.4161/hv.28332

Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine

Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination

Despite the high success of protection against several infectious diseases through effective vaccines, some sub-populations have been observed to respond poorly to vaccines, putting them at increased risk for vaccine-preventable diseases. In particular, the limited data concerning the effect of obesity on vaccine immunogenicity and efficacy suggests that obesity is a factor that increases the likelihood of a poor vaccine-induced immune response. Obesity occurs through the deposition of excess lipids into adipose tissue through the production of adipocytes, and is defined as a body-mass index (BMI) ≥ 30 kg/m2. The immune system is adversely affected by obesity, and these “immune consequences” raise concern for the lack of vaccine-induced immunity in the obese patient requiring discussion of how this sub-population might be better protected.

but it got jannied