I've never run Mint or Debian on my home desktop but those seem like the obvious options.
I'm not installing Gentoo or Arch because my choice of distro is not based on insecurity about my peepee size and I'm looking for everyday ease of use and a large support base.
edit: currently installing mint debian edition pray for me brothers
edit2: mint debian thus far seems better/less buggy than ubuntu without major downsides 
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debian desktop has been very nice
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