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:marseyneko: Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations | Neurochemical Research :marseydramautist:

https://link.springer.com/article/10.1007/s11064-023-04089-2

BNT162b2 = Pfizer–BioNTech

Abstract

The COVID-19 pandemic catalyzed the swift development and distribution of mRNA vaccines, including BNT162b2, to address the disease. Concerns have arisen about the potential neurodevelopmental implications of these vaccines, especially in susceptible groups such as pregnant women and their offspring. This study aimed to investigate the gene expression of WNT, brain-derived neurotrophic factor (BDNF) levels, specific cytokines, m-TOR expression, neuropathology, and autism-related neurobehavioral outcomes in a rat model. Pregnant rats received the COVID-19 mRNA BNT162b2 vaccine during gestation. Subsequent evaluations on male and female offspring included autism-like behaviors, neuronal counts, and motor performance. Molecular techniques were applied to quantify WNT and m-TOR gene expressions, BDNF levels, and specific cytokines in brain tissue samples. The findings were then contextualized within the extant literature to identify potential mechanisms. Our findings reveal that the mRNA BNT162b2 vaccine significantly alters WNT gene expression and BDNF levels in both male and female rats, suggesting a profound impact on key neurodevelopmental pathways. Notably, male rats exhibited pronounced autism-like behaviors, characterized by a marked reduction in social interaction and repetitive patterns of behavior. Furthermore, there was a substantial decrease in neuronal counts in critical brain regions, indicating potential neurodegeneration or altered neurodevelopment. Male rats also demonstrated impaired motor performance, evidenced by reduced coordination and agility. Our research provides insights into the effects of the COVID-19 mRNA BNT162b2 vaccine on WNT gene expression, BDNF levels, and certain neurodevelopmental markers in a rat model. More extensive studies are needed to confirm these observations in humans and to explore the exact mechanisms. A comprehensive understanding of the risks and rewards of COVID-19 vaccination, especially during pregnancy, remains essential.

Conclusion

... It's imperative to recognize the limitations of our research, given that it relies on animal models. Caution should be exercised in generalizing these results to humans. Further rigorous clinical studies are required to confirm these observations in human populations and to ascertain the exact mechanisms at play.

Given the public health significance of understanding the effects of COVID-19 vaccination, especially during pregnancy, comprehensive studies are vital. These should weigh the benefits and potential risks of vaccination, focusing on ensuring optimal neurodevelopmental outcomes. Our findings underscore the importance of continued research in this domain to guarantee the safety and well-being of all individuals, especially those who are pregnant and their offspring.

In summary, this study provides valuable insights into the effects of the COVID-19 mRNA BNT162b2 vaccine on the WNT pathway and BDNF levels, particularly in relation to neurodevelopmental outcomes. The observed male-specific vulnerability and the convergence with existing literature support the involvement of these molecular pathways in neurodevelopmental disorders. However, further research is warranted to validate these findings in human populations and to unravel the complex mechanisms underlying the observed effects. The ultimate goal is to ensure the safety and well-being of individuals receiving COVID-19 vaccination, particularly during pregnancy, while minimizing potential risks to neurodevelopment.


Now remember, this is in RATS. So don't go and jump to any conclusions about human population!


orange site

https://i.rdrama.net/images/17052703131023655.webp

orange site baleted

:marseyjannysuspicious:

!nooticers

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Chud disinformation. It's safe and effective, the tv wouldn't lie about something this big. And everyone know this

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Nothing happened to the overwhelming majority that took the vax. But give it 4 more weeks, surely we'll see people dropping dead enmasse and you can live your rightoid fantasy.

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the fact that they were only sort of dangerous was definitely a win for team tv

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I'm not doubting people had issues, in fact, I'm skeptical myself. But the rightoids acting like it was a mass culling event and all that shit are giga fricking r-slurs.

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Aggravating, isn't it. No caution or doubt, just straight to genocide. Wingcucks getting a public voice is one of the worst things about the internet.

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wingcucks getting a public voice

one of the worst things

*best things, actually. made the world see how r-slurred they really are :marseylaugh:

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Only when they're treated as r-slurred rather than listened to.

Also tbh I knew they were r-slurred, I've seen far too much evidence they're r-slurred, now I'd just like them to shut up, or at least shit up other places.

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That's fair enough tbh. The general rule in life is that the r-slur :marseyfoidretard: is funny to watch but you would never want to live with them for more than a few days at most.

There are times in my life when i am all for open speech :marseyfreezepeach: and times when i want to see entire countries :marseytunaktunakgenocide: and ideologies :marseywingcuckgenocide: rangebanned from the internet. Can't decide

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Red deer

:marseyreindeer3:

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actual vaccines were pulled off the market when drmatically lower levels of side effects were noted, in less-corrupt periods of history

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The vax only exists now to grift money out of demented boomers already dissolving in a stew of pharmaceuticals. No one is buying into the "you need a subscription service to avoid the coof" nonsense

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Dude think about it for half a second. If it did cause these effects in 99% of prenatal infants, all those mommies who got vaxxed have kids like 2-4 years old right now. Maybe we just haven't noticed because kids are r-slurred naturally and they're all gonna get diagnosed with autism in 5 years.

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>vaccines cause autism

lmao

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The pfizer covid one apparently does. In rats. What's to lmao about

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^rightoid thinks vaccines cause autism

Lmao

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Yes. Trust the science

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They don't though.

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https://media.giphy.com/media/3oz8xLd9DJq2l2VFtu/giphy.webp

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Luckily most governments imposed unilateral releases of all claims so that the manufacturers cant be inundated with meritless lawsuits for their selfless work in saving us from the pandemic!

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Think about how many lives the big evil pharmaceutical industry saved. The thing about corona viruses is that you always want to vaccinate against them, it's settled science

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