I just made my first batch of yellow science.
Blue circuit production and various other things.
Red circuit production with uranium processing barely visible on the left.
Green circuits (yes I am aware this is nowhere near enough production), science 
, my early coal power, and my newly minted nuclear reactor.
Solar power and accumulators. The scale is completely unnecessary now that I have nuclear power up and running but it will be useful again some day.
Smelting setup for a double line of copper plates.
Fluid processing. I haven't played in a while but fluid processing seems a lot easier than I remember. I spent like half an hour setting it up and since then I have barely had to even think about it.
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Nice main bus
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15 minutes of planning at the very beginning of a playthrough pays off through the entire rest of the game
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Do you do all the math to calculate what you'll need?
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No I am very laissez-faire with my manufacturing. I take a guess at what I'll need and throw down assemblers lol. If I seriously underestimate how much I'll need of a resource or item I'll rework it to fix it if it's important but most of the time if the ratios are a bit off I'll just leave it how it is.
For the bus I just kinda know from experience which resources and how many lanes of each I'll need for my initial base.
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I think I'm gonna have to start using spreadsheets or something because my factories are always horribly ugly and I'm constantly having to tear down parts of it.
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Yup it's how I am. I'll run around as radar is ticking to make sure to mark all the mining spots and plan accordingly and where I want my bus highway to grow.
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