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Are there any drugs that cause fast acting depression and sadness? (like the opposite of MDMA)

I've been wondering this for a while

17
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Probably something that guarantees a bad trip like Benadryl

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The sparkle gremlins were ultimately harmless.

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yea but i think dosage matters to get exactly what he wants. and it also comes with brain damage so he prolly not goin for this one

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