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Are there any drugs that cause fast acting depression and sadness? (like the opposite of MDMA)

I've been wondering this for a while

17
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suppose the right dose of alcohol or a deliriant. maybe a little under a threshood dose of the deliriant

even though i feel great on opiates ppl often tell me i look sad n shit like "cheer up". but thats just how i look not how i feel

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