https://old.reddit.com/r/chemistry/comments/1fznu5u/nobel_winners_in_chemistry/
!ifrickinglovescience !chemistry !biology
For their work at AI to predict protein structures (AlphaFold)
Also
Gook foid wins Nobel Prize in Literature
!bookworms here's my double Nobel thread
Reminder that Alfred Nobel was a based chemistchad
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Shit if you handed this capability to a chemoid 100 years ago we would have flying cars by 2015.
Yeah, living forever and knowing the future is the whole point of science.
Also gooks in chemistry shouldn't be a surprise. My Organic Chemistry lab TA was named Ping Pong Ching Chong Mi So Honee Mi Ruv Yu Rong Taim.
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from the /r/chemistry thread
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That's literally just because sc*entists are r-slurred and think there's a magical, god-given distinction between """real""" experiments and computation.
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Computation gives you a theoretical model and nice pretty curves. They still need to be considered academic.
Running actual experiments validates models and refines them. But it also introduces discrepancies which force you to improve laboratory procedures, develop more refined equipment, or you discover a new fundamental truth which explains the discrepancy.
"Why the frick is Uranus so weird?"
do theoretical math
"There's probably another planet out there messing up its orbit due to gravity and shit, and mathematically it must be X far away and by Z mass."
"Yep there it is"
That's why you combine theory and practice.
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Another r-slur who just handwaves "there's actual experiments which are different from theory because they just are okay????"
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Reality has a surprising amount of detail
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KEYLOGGER
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The bread crumbs are piling up. After some tracking I found your IP: 141.11.191.246
Out of luck, son (snap)
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If actual experiments differ from theory, that just means the theory needs to be updated.
Some stuff in physics matches REALLY well, particularly quantum physics. Like Feynman would always brag that for a few key quantities, the theoretical value and experimental values only differed by like 0.0000000000001%.
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That's still stuck in this same r-slurred mindset that "actual experiments" have priority over theory, simulation, etc. Scientists question ur assumptions instead of accepting dogma uncritically all the time challenge IMPOSSIBLE
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No it's not, it's just clear fact.
The purpose of theory is to predict reality. If it doesn't match the reality we can directly measure, then it won't match the reality we can't (or simply don't want to for cost etc reasons).
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Case in point
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!ifrickinglovescience !chemistry !biology is Borpa (a biochem) right on the Soyentism question?
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Yes kill all scientagicians (this is a fusion of the words "scientist" and "magician", implying that scientists are a lot like magicians.)
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the entire point of science is doing math to try and predict observation, then adjusting math to fit it better (or adjusting observation instruments/methods to be more accurate). Without observation you don't have science.
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Literally uncritically regurgitated dogma lol worse than religioncels
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@SpookyBorpa is doing an r-slur's impersonation of Kuhn (maybe with a pinch of Popper) insinuating that interpreting experimental data, or even deciding what experiment to perform in the first place, is impossible outside of some theoretical framework, therefore doing an X-Ray crystallography on some protein you synthesized is just as prone to failing to predict its actual properties as simulating it on a computer (it's not obviously, let's hope that borpa's baiting and not a literal r-slur).
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The only phil of science this STEMcel knows is Popper and Kuhn, what a classic 😂😂😂 FYI both are completely irrelevant for contemporary phil of science and questions about the epistemic status of non-physical experiments. It's completely uncontroversial (in phil of science departments (aka smarter ppl than STEMcels)) that computer simulations create the same kind of evidence that """actual experiments""" do
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LMAO does this person really not understand why computational models of protein structure are useful?
Hint: if you want to create a molecule that has some desirable characteristics, it's a lot better to run a computer simulation over 1000 designs and physically test the most promising one, than to physically test all 1000.
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So far, that approach hasn't really borne fruit. It may in the future, but so far it still works better just to do a giant screen and see what hits.
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How do you choose which drugs to screen, considering there are far more options that you can afford to test?
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Round up more hobos, dummy.
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High throughput can scan thousands of compounds. Typically you would run compounds you already know work, some that have similar characteristics, some that have very different characteristics, and some that work for other purposes. They are typically extremely small amounts of natural products for each sample so pretty cheap and fast.
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You have billions of possible options, How do you choose a batch of several thousand from that?
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They are usually compounds known to be safe in humans. Huge libraries exist of either natural products or medications for other diseases. You can also take a compound you know binds to a certain protein or receptor and get crystallography data to determine what would best fit in the binding pocket. You don't need the best possible option, you just need a starting point for synthesis of derivatives.
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There are giant libraries of "drug-like" molecules that you use. They tend to be biased towards molecules that are easy to make by chemical manufacturers, which yes, is a problem. When a new good reaction comes along you'll often get new classes of compounds out of that. Depending on your target, you know what's had some interaction in the past, so you start with stuff that looks like that.
Once you get a hit or several, the compound isn't good enough as-is, so you start modifying it. In theory, computations could help you here as well, and maybe it's starting to, I don't know. Start making chemical modifications, see what helps it hit the target better. Of course, it has to do other stuff too: get into the target organs, not degrade too quickly, not be too toxic. There's various things you can try to make each of those better, but it's still largely guess-and-check. And usually it doesn't work. There's a reason that new medicine is expensive: it needs to not only pay for its own R&D, but also the R&D of everything that hasn't panned out.
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People don't even confirm a chemical compound with GC retention time without an orthogonal column or a Mass Spec.
Are redditors actually r-slurred?
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no, in this case it's contrarian dramatards who are. as of yet nothing useful has come out of it (one reason to get a nobel) and it's not really groundbreaking on the theoretical side (other reason to get a nobel). In 10 years it will most likely have the former but as of now it's mostly used to get mid science past peer review (ask me how I know )
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They're called helicopters sweaty
Sometimes they fall out of the sky
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The gook was the literature winner not the sciencecels. You rushed so hard to respond you didn't even get the basics correct.
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I don't believe this was their actual name.
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Huong Dong
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Chemcels kept complaining that the chem nobel keeps going to biologists and the comitee doubled down lol
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chatgpt empowered DYI-vaccines when?
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It's over for Scels. They're going to the back of the unemployment line with the liberal arts chaff
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@KatserKitty1987 how long until chatGPT can do DNA sequencing?
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Huh? DNA sequencing is the physical technology of reading physical DNA and getting the base pair sequence. AI can't really help with that. If you mean like finding exons and stuff there are computational and statical methods to find genes from DNA sequencing but you need to review it as machines often times get results which are statistically correct but biologically wrong. !biology Right now computational stuff in biology is kinda shaky and I expect there will be a scandal with single cell sequencing as the current methods of cell type assignment methods are mathematically shaky and built on other shaky research.
ChatGPT is fricking r-slurred and if I have another group member submit their part of an essay as a bulleted list divided into sections with lots of flowery BS language I'll sent angry emails to openAI. Like bro no one was writing like this before chatgpt and now everyone is writing like this. lol
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yes but AI is great at bullpooping and publishing fake but plausible results, which is good for your budding science career
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With utmost astonishment, we bear witness to the recent and extraordinary transformation in the quality of written assignments, a metamorphosis meticulously orchestrated by the advent of ChatGPT, culminating in a state of affairs that is, quite frankly, absolutely absurd.
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Would we need a humanoid robot to completely automatize what you do on the lab?
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Sequencing is already automated in the sense computers do it. We just need humans to prepare the isolation and the libraries. The big revolution will be pacbio and Oxford nano pore sequencing becoming cheaper as it means we can finally move away from short read illunmia sequencing which kinda sucks for genome assemblies as the read lengths are short which creates a lot of ambiguity in high repetitive genomes and genome sections. Nanopore is esp cool. It is done in devices which are smaller than a modern smartphone and can be connected to any laptop or phone with USB. It means you can do live sequencing of DNA in the field and have all the data directly transferred to your devices.
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ESL speakers have been hit hard by grammarly and chat gpt
I miss charming engrish emails
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Here are some key ways ChatGPT can improve human communication:
Enhanced Interaction and Engagement: ChatGPT enables seamless communication between users and AI systems, fostering better interaction and engagement. It can simulate emotional responses and provide a more humanized communication experience.
Improved Communication Skills: ChatGPT can help users improve their communication skills through targeted prompts and roleplay scenarios. For example, users can practice communicating with difficult colleagues or managing relationships with people who have specific communication styles.
Personalization and Efficiency: ChatGPT can tailor its communication style and responses to individual users, making interactions more personalized and efficient. This can lead to better understanding and more productive exchanges.
Clarity and Plain Language: ChatGPT can help users communicate complex information in clear, plain language that is easier for others to understand. This is particularly useful in fields like healthcare, where effective communication is crucial.
Empathy and Emotional Intelligence: By simulating emotional responses, ChatGPT can help users develop greater empathy and emotional intelligence in their communication. This can lead to more meaningful and impactful interactions.
Continuous Improvement: ChatGPT can continuously learn from user feedback and dialog data to enhance its own communication abilities over time, providing an ever-improving experience for users.
In summary, ChatGPT's natural language processing capabilities, personalization features, and capacity for continuous learning make it a powerful tool for enhancing human communication skills, clarity, and engagement across a variety of contexts.
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Wow, I must make counter arguments to this that are totally mine and mine alone.
1. Enhanced Interaction and Engagement:
While ChatGPT aims to enable seamless communication between users and AI systems by simulating emotional responses and providing a more humanized experience, this can lead to a superficial understanding of human emotions and interactions. The AI does not possess consciousness or genuine feelings, so any emotional responses are generated based on patterns in data rather than real empathy or understanding. This simulation might mislead users into believing they are engaging in meaningful interactions, potentially diminishing the value they place on genuine human connections. Moreover, reliance on AI for interaction could reduce opportunities for individuals to develop and refine their interpersonal skills with real people.
2. Improved Communication Skills:
Counter-Argument:
Although ChatGPT can provide users with scenarios to practice communication, it cannot fully replicate the complexity and unpredictability of human interactions. Real-life conversations involve nuanced emotions, body language, and spontaneous reactions that an AI cannot authentically reproduce. Practicing with an AI might give users a false sense of confidence in their communication abilities without adequately preparing them for the challenges of engaging with real individuals who may not respond in predictable or programmable ways. This could ultimately hinder personal growth in communication skills rather than enhance it.
3. Personalization and Efficiency:
While personalization can make interactions with ChatGPT more efficient, it may also lead to a narrowing of perspectives. By tailoring responses to individual preferences, the AI might inadvertently reinforce existing biases and limit exposure to diverse viewpoints. This echo chamber effect can hinder critical thinking and reduce opportunities for users to challenge their own assumptions. Additionally, over-reliance on AI for efficient communication might diminish patience and tolerance for the natural pace and complexity of human conversations, potentially leading to frustration or disengagement in social settings that do not offer the same level of tailored responsiveness.
4. Clarity and Plain Language:
Although simplifying complex information is valuable, ChatGPT's interpretations may sometimes oversimplify or misrepresent critical details, especially in specialized fields like healthcare. Nuances and subtleties that are essential for accurate understanding might be lost, leading to misunderstandings or misinformed decisions. Relying on AI to convey important information could also discourage individuals from developing the necessary skills to comprehend and communicate complex concepts themselves, potentially leading to a general decline in subject matter expertise and critical literacy skills over time.
5. Empathy and Emotional Intelligence:
While ChatGPT can simulate empathy through programmed responses, it lacks genuine emotional intelligence. The absence of true consciousness means it cannot authentically understand or share the feelings of users. This simulation might lead to interactions that feel hollow or unfulfilling upon closer reflection. Furthermore, using AI to develop empathy could be counterproductive, as it does not provide the rich, reciprocal feedback that comes from interacting with real people. This might impair a user's ability to read and respond to genuine emotional cues in others, ultimately hampering the development of meaningful human relationships.
6. Continuous Improvement:
Even though ChatGPT can learn from user interactions, its learning is confined to patterns in data rather than genuine understanding or creativity. The AI's improvements are bound by its programming and the quality of data it receives, which may include biases or inaccuracies. Continuous learning without proper oversight might reinforce and amplify these biases, leading to inappropriate or harmful responses. Additionally, users might develop unrealistic expectations about the capabilities of AI, potentially leading to overdependence on technology and underestimation of human judgment and expertise.
In Summary:
While ChatGPT offers impressive natural language processing abilities and the promise of enhanced communication, there are significant concerns regarding its impact on human interaction. The reliance on AI for engagement and communication could lead to a decline in interpersonal skills, reduced appreciation for genuine human connection, and potential reinforcement of biases. The limitations inherent in AI—such as the lack of true empathy, consciousness, and understanding—mean that it cannot fully replicate or replace the depth and richness of human communication. Therefore, it is crucial to approach the use of ChatGPT with caution, ensuring that it serves as a tool to supplement rather than supplant authentic human interactions and personal development in communication skills.
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😴😴😴
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Sorry ma'am, looks like his delusions have gotten worse. We'll have to admit him.
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ChatGPT can already tell you a synthetic route if you give it an IUPAC name.
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If they keep training the model on Reddit, maybe in 2077
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But think of how many pronouns Reddit will teach the ai in the meantime
Putting the in
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"lol learn to code"
"if your job is threatened by immigrants, I guess you aren't very good at your job/your job isn't important"
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This but unironically.
Coding is the industry with the most future scope left.
Immigrants are brought in to do the jobs that slaves used to do. You are literally complaining about not getting the jobs nobody wants anyways.
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Lmbo, Hinton also won the Nobel prize for physics. Non codecels are getting cucked.
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that one i actually feel bad for physicscels
the chem prize made most sense since it was a big breakthrough
the physics one was a big stretch
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What's so special about proteins? Just get whey at the supermarket
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Just get your protein sourced directly from your gymbro
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Thr body has ways of making its own
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Just fold your own
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WRT the winning book I'll share this excerpt from St. Augustine's Confessions, book 3, Chapter 2 "In Public Spectacles He is Moved by an Empty Compassion. He is Attacked by a Troublesome Spiritual Disease":
I think about this quotation a lot and find his condemnation of a "false and empty compassion" borne out of media provocative. Thoughts?
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Demis was a high level employee of BVLLFROG and had close ties to Peter Molyneux.
G*mers win again.
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Computational chemistry is a pretty big field and their work was really impressive from what I can tell, so I'm not surprised at all
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What's surprising is that their Nature paper was published in 2021 and that they won the Nobel just 3 years later. Normally it takes more than a decade for sciencecels work to be acknowledged.
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Even the nobel commitee is in love with AI
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It's how you know it's a bubble about to pop.
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Computational chemistry is cool as frick and I used that back in the day to come up with new things to synthesize. The biggest problem with the computational methods was that they were prone to falling into local minima for structures when minimizing energy, so I bet AI would really help there. Actually might go read the paper but I wasn't a code guy just dabbled in their programs.
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Biochemistry/bioinformatics chads win again
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This can't be the way that I learn that my old boss got the Nobel...
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Unnecessary and uncalled for ping two more strikes and you're getting blocked + megadownmarseyd buddy, don't test your luck
Snapshots:
https://old.reddit.com/r/chemistry/comments/1fznu5u/nobel_winners_in_chemistry/:
undelete.pullpush.io
ghostarchive.org
archive.org
archive.ph (click to archive)
https://www.reuters.com/science/baker-hassabis-jumper-win-2024-nobel-prize-chemistry-2024-10-09/#:
:text=STOCKHOLM%2C%20Oct%209%20(Reuters),areas%20such%20as%20drug%20development:ghostarchive.org
archive.org
archive.ph (click to archive)
https://theguardian.com/books/2024/oct/10/south-korean-author-han-kang-wins-the-2024-nobel-prize-in-literature:
ghostarchive.org
archive.org
archive.ph (click to archive)
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People were complaining about them winning?
idk...my own biochem professor had a whole lecture telling us about AlphaFold and how it was, akshually, a good thing so idk here lol
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