"The Powerpuff Girls used to be America's pint-sized superheroes. Now they're disillusioned 20-somethings who resent having lost their childhood to crime fighting. Will they agree to reunite now that the world needs them more than ever?" the series' description read at the time. In March 2021, it was announced that Dove, Chloe and Yana were cast as the three crime-fighting sisters with Donald Faison as Professor Utonium and Nicholas Podany as Mojo Jojo.
Nearly a month after filming the show's first episode, it was reported that the show was being reworked for the network. Variety noted that the show's leads "remain attached to the project" with plans to "film a new pilot for the series off-cycle." Then, Mark Libertarianwitz, The CW president and CEO, explained why they decided to hold off on the show during a May 2021 conversation with reporters.
"The reason you do pilots is because sometimes things miss, and this was just a miss," he said, per Variety, noting that the network believes in the cast, crew and studio. "In this case, the pilot didn't work."
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