Study confirms the "chemical imbalance" is a meme and seratonin has nothing to do with depression. An entire generation of brain addled SSRI zombies copes
https://old.reddit.com/r/science/comments/w4ioxk/the_serotonin_hypothesis_debunked_in_a_recent
Scientology is right about psychiatrists.
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Darn so i fricked up my peepee by taking meds for nothing huh
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https://www.amazon.com/Flordis-Remotiv-Stress-Relief-Tablets/dp/B00AR6SAKO but it really does have to be this specific stupid expensive brand, I know it sucks. Give it at least a week to see results.
Also probiotics, bad gut bacteria is serotonergic
Also find the research saying dextroamphetamine is a cure and cop some Adderall from your doctor
it doesn't actually do anything but there's enough research saying it might to convince some psychs
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These things are even more of a meme than SSRIs
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I'm not about to explain a multiaxial etiology on my phone, but cope. Definitely a meme that something proven to upregulate 5ht1a postsynaptic receptors might improve SSRI side effects
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Can you tell me what a 5ht1a postsynaptic receptor does? I don't care if anybody believe it, I'm just tryna help point other people suffering like I used to in the direction of what helped, and there's very solid neuroscience behind it
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Then why not just link to a single peer-reviewed study that even remotely supports your schizopothesis.
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here I can link you to hundreds! https://scholar.google.com/scholar?hl=en&as_sdt=0%2C1&q=st+john%27s+wort+5ht1a+upregulation&btnG=
https://www.sciencedirect.com/science/article/pii/S0166432808007171?casa_token=NjjqvkM14zMAAAAA:apDyW4uVX5JWeIWQU1-zIY804xvnpScyyvOUVe70NQsHDM-c9tZBVWVA-e767AYJuQGlXofF
https://www.nature.com/articles/4000557.pdf?origin=ppub
https://journals.sagepub.com/doi/pdf/10.1177/026988110101500109?casa_token=uSmksWjPfzoAAAAA%3AVT_hIYEXqdfZhwKSOrr6E1r1mSx-kPO35dpJyNmx8MhNFLBewMq2lhXlP_HGAn49_8YZifkiwHY&
Here's one about the specific cultivar I recommended! https://pubmed.ncbi.nlm.nih.gov/11518078/
And testimonies from thousands of other people https://www.google.com/search?q=st+john%27s+wort+pssd&oq=st+john%27s+wort+pssd
Isn't it neat that you can find that stuff in like 5 seconds? What a time to be alive! It's been extensively studied for decades and used for this exact purpose by tens of thousands of men. Now quit being a lazy brainlet and don't make me do this emotional labor for you again.
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Based educatedcel
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Thanks for doing all the work for me nerd. I was kinda interested.
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7 =/= 100
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Trust the indigenous science bigot
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"Listen up, you White peepeesucker, many moons of research and peer reviewed studies prove that smoking my ancestors testicles will heal the forest."
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I put enough Adderall up my nose during college to last me the rest of my life, im good on that one
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Do try the extract though, it's very effective. Standard US brands don't do shit because herbal supplements in America are a meme, and this one is a very unique cultivar that's been studied more than most normal pharmaceuticals
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You donβt need to drop that much. Most people are kitties and donβt understand that herbs are extremely weak and diluted because theyβve been spoiled from super prescription strength pharma concentrated drugs. I didnβt realize this until I started kratommaxxing and taking the weak powder capsules by the fist-full. Herbs donβt do shit unless you eat 10 times the normal dose, no fricking shit itβs incomparable to perfect laboratory grade potency drugs. Iβve had this discussion multiple times with my family, yes the herbs are a total fricking scam: therefore if you eat half the entire bottle simultaneously, you might get a slight tingle of effect.
You need to take super concentrated herbs? Lol what an r-slur, just take 15 normal caps from the pharmacy where theyβre 75% off + bogo because only you and five other insane people plus one desperate person with cancer are the entire customer base.
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It's a specific cultivar, not just a stronger concentrate. I could longpost about the specific chemistry but blah blah low levels of the ickier chemical hyperforin, high levels of the good chemical hypericin. Unlike literally any other brand you can find on Earth. Disregarding that American herbs are literally 100% unregulated, which is way too sketchy for me. I'm out here trying to FIX problems bad chemicals caused, not give people more.
There's more to this than just smashing back some ground up flowerbuds, I mean this stuff would probably grow in my lawn if it wasn't mowed, it grows everywhere and is toxic to livestock so it's actually illegal to not kill it on sight in many places. But it would either not do nothing or cause serious issues depending on how much you take.
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Just take a different herb which counteracts the one you donβt want, isolating it sounds do like a huge pain in the butt when itβd be easier to just negate it. Or just have a better liver and have good genes
. You donβt need to be a little b-word, some negative side effects are normal, and in kitty herbs like SJβsW itβs literally nothing.
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I don't think there is anything that counteracts this specific chemical that's only known to occur in a single species of plant and which we actually have no idea how it does what it does, but I like where your head is
Ironically the biggest problem is that it actually makes your liver too powerful for other medications to work
If someone takes typical SJW with other serotonergic drugs it can literally kill them (and I'd still be very careful taking this "safer" version with one too), it's very systemically impactful. You might not be getting a high but it's arguably the most bioactive plant on the planet.
All that aside this is simply more effective since it's more dopaminergic than other cultivars, which helps solve the original problem
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Why would you take SJW while on serotonergic drugs, thatβs just asking to frick your system up for a long time, like taking Uridine Monophosphate and dopaminergic drugs like adderall simultaneously will slow down your tolerance building but make it take way longer to recover.
Also, the most bio active plant psychiatrically is probably ayahuasca.
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since when did people start snorting adderall? I remember my mandated college drug awareness course saying that injecting adderall was βpopularβ, Never seen anyone do it tho.
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People have been snorting it for a long time but thatβs a waste itβs best just eaten in large quantities
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When i was on the extended releases i found the best was to pour some crystals in my mouth and chew
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The quick releases are similar enough to other snortables that pillheads were doing that shit on instinct like immediately lol.
Got my first prescription and the first thing my cokeheaded friend says is βbro i bet these are stronger if we snort themβ
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Whoaaaa
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This neighbor doing alchemy in Elder Scrolls Oblivion and called it science
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Upregulates 5ht1a postsynaptic receptors &
1 receptors & striatal dopamine
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Yup, commonly taken after abusing MDA/MDMA
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That fricking shit negatively interacts with everything
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Aside from serotonin syndrome (which won't happen if you're not on another serotonergic drug or just take way too darn much) its problem is that it makes you metabolize other drugs so fricking fast they stop working. Off the top of my head I know it turns birth control pills into a placebo, and cyclosporine. It's also recommended to stop taking it for a week or two if you know you're going under anesthesia though I've not found much evidence to really back up that contraindication. Not that it would kill you, just jack up the required dose of anesthetic.
Which is to say you need to be thorough in your own research and careful about taking random bioactive pills without checking for interactions. Being an herb doesn't mean it's safe for the same reason that doesn't mean it's ineffective, though the reason I recommend this very specific ludicrously-priced brand is that it's seemingly the only one on the fricking planet that's standardized to a low hyperforin content, which is the chemical that causes most of the bad interactions. Thankfully the side-effects in isolation are almost literally nothing.
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can i have a happy life without pumping myself full of non essential pharmaceuticals?
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You specifically? No.
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Do probiotics have any evidence of positively effecting the gut microbiome? I know kombucha has literally 0 evidence of positive effects, yet its sold fricking everywhere.
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Neighbor get some actual lactobacillus not hippy dippy mayofoid tea. We're specifically trying to treat SIBO. I like nature's bounty probio 10
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Im not r-slurred. I donβt drink kombucha, it doesnβt even taste good. Are there any studies about ingesting lactobacillus positively affecting the microbiome though? I feel like mfers need to stop drinking 4 days a week and thatβd help more.
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There isnβt any evidence that simply consuming live bacteria is enough to have it effect on gut flora. I looked into this a while ago because I loved drinking Yakult and wanted to know if it was actually good for me or just sugar water. I still drink it but as a treat and not a every day thing now.
The issue is just a matter of the stomach being good at itβs job (killing everything with acid) and the total amount of bacteria consumed being negligible compared to the amount of bacteria that already lives in you.
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You gotta boof it. So says the science
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Fecal transplants niqqa
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shooting streams of yakult from your butthole after an enema sounds way hotter tho
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Yes this was my point. Also yakult is great.
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Yakult is sweeter than coke
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There are tons of drugs that have enteric coatings, though I don't know if I've seen any probiotics that do.
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As someone with GI issues that stuff like Yakult and other probiotics have never helped me. Doesn't mean they don't work, could just be that my GI problems aren't necessarily a gut flora issue
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If it were that easy to directly effect gut flora we wouldn't need fecal transplants. Going through the back alley makes more sense than braving the pit of acid. Yogurt is still yummy and nutritious though
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As someone with some extra serious GI issues involving diarrhea+ visible bleeding they actually help a lot but it's a "when you're already fricked" or "starting to feel it's gonna get bad" kinda thing, not for when you're healthy
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Counterpoint, lactobacillus cultures have been shown to grow testicles in mice and anecdotally work in humans too. Happy balls = happy life
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084877
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Just start fermenting some veggies. Some fermented cabbage is awesome on sandwiches and is full of lactobacillus.
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I already make spicy kimchi with carrots, daikon, and green onions.
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Then you good. That has more lactobacillus than any supplement you're going to take.
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Whatβs your address, let me ship you some kimchi!
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It's been shown to be as effective as antibiotics for curing SIBO
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Does it cure SUGMA?
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Ginger kobucha is great when you are hungover or sick, thatβs all I got
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You have to shove it up your butt
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I don't know what to believe anymore. Apparently a lot of vitamins in pill form aren't even metabolized by your body properly and may be a waste. Not all of them but some of them
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Yup this is true, not every form of a molecule is bioavailable.
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In general I take vitamins more as a way to help supplement anything youighy have missed from your food so you don't develop a deficiency than as any boost to health. It's useful for example when your stomach is fricked and you can only handle some crackers
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St John's Wort always makes me think of this funny erowid submission about a lawyer who shits himself on it
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You're making it sound way too complicated. He just has to balance his chakra.
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did any of you research turn up anything on haloperidol? I'm on a very low dose and just hoping I don't get the serve reactions.
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Never heard of it, nope. But if there's a serious risk of reactions I'd look into safer alternatives first. If you're not on anything serotonergic anymore I think that link is the best first-line suggestion.
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good to know thanks
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Just look into interactions with anything else you take, since it boosts metabolism of some drugs to the point that they become ineffective.
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I was on a shit ton of meds before (meds for med's side effects...) and now I'm just on this low dose of haldol / haloperidol with OTC stuff.
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more a risk of non-reactions... look up the word
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bullshit
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https://rdrama.net/post/87688/marseychemistmarseydoomerstudy-confirms-the-chemical-imbalance-is/2356049?context=8#context
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there were thousands of studies on priming and chinese traditional medcine and ayurveda and ESP. tens of thousands on how fat causese heart disease. science is hard. a lot of science is wrong.
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Definitely, but bottom-level neuroscience (what drugs have what effects on what transmitters/receptors) is a rock solid science. I don't trust a dozen studies saying what it can treat, but a hundred studies saying it impacts a specific receptor is effectively gospel, and more than anything it worked for me like night-and-day after a dozen other things had zero effect
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profoundly confused. low level neuroscience has a lot of hard science, but we have no idea what any of those 'specific receeptor effects' mean in relation to more complex / larger scale relations. We know that SSRIs do all sorts of things at all sorts of receptosr, and same for all the other drugs, but have a bunch of very bad gusses for why that causes any observable dfferences in experience
more importantly, all depressed people are so because their position in and relation to modern society is based on a large stack of deceptons and fake images. they should be depressedand * should* want out, and trying to chemically fix that is just forcing yourself to forget what you've lost
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this isn't about depression, this is about how we know that pumping up 5ht1a receptors makes rats c*m instantly, discrete physiological effects rather than convoluted psychological mumbo jumbo
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Well, maybe you get to be in the class action lawsuit
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Can't wait for my $17.38 from the future class action for the Covid vaccines.
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What a specific number, were you too a party to the Safeway Gas Receipt Lawsuit?
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Sylvania Lighting Systems for their bogus Silverstar headlight bulbs.
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Ayyyy. I got $4.76 in stolen wages from a prior employer several years later. Except, that fricking sucks, because I had to report it as income. Wasted a whole 4 mins of my time typing it into the tax software + double checking it.
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Nah, that was the Heem Litness Lawsuit from the law offices of Fetty, Wap, and Trap Queen
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hey now, last class action I was in (against facebook) I got around $400
thanks zuck!!
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Subtract $2.50 for legal fees
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Serves you right druggie.
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Inshallah
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It all depends if you actually feel better or not.
There is some evidence that SSRIβs alleviate symptoms of depression, the problem is that no one knows why it works when it does. Although tbh, the impression that I get is that they have a pretty minimal effect.
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Adderal + SSRIs + Viagra + Xanax + other fun drugs = medically induced good times
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BIPOC just do coke
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drug companies also don't publish bad evidence, so the evidence is skewed.
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Yeah, but thatβs true for all drugs, regardless of actual efficacy, and true for pretty much any published study nowadays.
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our science is very much limited by trying to squeeze knowledge by extrapolating from small batches instead of doing constant whole society monitoring.
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To be fair, there's a lot of shit that we actually have no idea why it works that we use everyday in medicine. We still don't know the mechanism of action for general anathesia. And I don't mean like for one commonly used drug, we straight up don't understand the MoA for how any of them work.
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Idk if I'd call them minimal. I was on zoloft as a teen for a while and it was night and day.
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It has a strong effect on mood, but it doesnβt really affect the other symptoms of depression and can make some of them worse eg insomnia, too much eating etc . Thatβs why it comes out as a wash in many studies.
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SSRIs are designed to be side effect free(they are not) and free from liability as if some rslur decides to take a whole bottle they won't die.
Old antidepressants like MAOIs and tricyclics are much more effective than ssris but they are rarely given to people that need them anymore
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What's up with the 2000 people online complaining SSRIs fricked them up and gave them "brain zaps" long after they quit taking them?
...also, what's up with Zoloft making my homie slice himself up and want to kill small animals? He quit taking that shit after starting to ramble that the universe was a simulation (he could no longer remember to take it), and then he took 2000mg of benadryl instead and got put in the hospital and then the mental hospital.
He was usually a pretty normal guy and has gone back to being normal so idk
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SSRI peepee fricked me up worse than actual depression. I was a horny 20 year old, which the medicine exacerbated, and suddenly it was taking me 2-3 hours to masturbate. Did I stop masturbating? No, I simply started sleeping less and cutting class, which negatively effected me in all other ways. Even now, three years off of it, I can't coom without hours of effort.
Kids, if you're reading this and your doctor tells you to take this goysloop, say no and insist on getting IV/nasal Ketamine. That shit actually works wonders.
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2-3 hours? You were rubbing that thing fricking raw
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Ketamine costs like 10k a dose though lmao
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Get insurance to cover it.
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i cant c*m now but at least i have the stamina to be pounding bussy into submission
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while SSRIs are in fact useless, this study doesn't prove that - it was already very well demonstrated the sarahtoenail hypothesis was wrong, it was even on wikipedia, and le mainstream claimed that various other mechanisms make them work. #r*pepsychiatrists
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