Study confirms the "chemical imbalance" is a meme and seratonin has nothing to do with depression. An entire generation of brain addled SSRI zombies copes
https://old.reddit.com/r/science/comments/w4ioxk/the_serotonin_hypothesis_debunked_in_a_recent
Scientology is right about psychiatrists.
- 224
- 190
Top Poster of the Day:
Thirtythirst4sissies
Current Registered Users: 28,720
BROWSE EFFORTPOSTS
SITE GUIDE
HOLES
PING GROUPS
Current software version: c889144
Jump in the discussion.
No email address required.
https://www.amazon.com/Flordis-Remotiv-Stress-Relief-Tablets/dp/B00AR6SAKO but it really does have to be this specific stupid expensive brand, I know it sucks. Give it at least a week to see results.
Also probiotics, bad gut bacteria is serotonergic
Also find the research saying dextroamphetamine is a cure and cop some Adderall from your doctor
it doesn't actually do anything but there's enough research saying it might to convince some psychs
Jump in the discussion.
No email address required.
I put enough Adderall up my nose during college to last me the rest of my life, im good on that one
Jump in the discussion.
No email address required.
Do try the extract though, it's very effective. Standard US brands don't do shit because herbal supplements in America are a meme, and this one is a very unique cultivar that's been studied more than most normal pharmaceuticals
Jump in the discussion.
No email address required.
You donβt need to drop that much. Most people are kitties and donβt understand that herbs are extremely weak and diluted because theyβve been spoiled from super prescription strength pharma concentrated drugs. I didnβt realize this until I started kratommaxxing and taking the weak powder capsules by the fist-full. Herbs donβt do shit unless you eat 10 times the normal dose, no fricking shit itβs incomparable to perfect laboratory grade potency drugs. Iβve had this discussion multiple times with my family, yes the herbs are a total fricking scam: therefore if you eat half the entire bottle simultaneously, you might get a slight tingle of effect.
You need to take super concentrated herbs? Lol what an r-slur, just take 15 normal caps from the pharmacy where theyβre 75% off + bogo because only you and five other insane people plus one desperate person with cancer are the entire customer base.
Jump in the discussion.
No email address required.
It's a specific cultivar, not just a stronger concentrate. I could longpost about the specific chemistry but blah blah low levels of the ickier chemical hyperforin, high levels of the good chemical hypericin. Unlike literally any other brand you can find on Earth. Disregarding that American herbs are literally 100% unregulated, which is way too sketchy for me. I'm out here trying to FIX problems bad chemicals caused, not give people more.
There's more to this than just smashing back some ground up flowerbuds, I mean this stuff would probably grow in my lawn if it wasn't mowed, it grows everywhere and is toxic to livestock so it's actually illegal to not kill it on sight in many places. But it would either not do nothing or cause serious issues depending on how much you take.
Jump in the discussion.
No email address required.
Just take a different herb which counteracts the one you donβt want, isolating it sounds do like a huge pain in the butt when itβd be easier to just negate it. Or just have a better liver and have good genes
. You donβt need to be a little b-word, some negative side effects are normal, and in kitty herbs like SJβsW itβs literally nothing.
Jump in the discussion.
No email address required.
I don't think there is anything that counteracts this specific chemical that's only known to occur in a single species of plant and which we actually have no idea how it does what it does, but I like where your head is
Ironically the biggest problem is that it actually makes your liver too powerful for other medications to work
If someone takes typical SJW with other serotonergic drugs it can literally kill them (and I'd still be very careful taking this "safer" version with one too), it's very systemically impactful. You might not be getting a high but it's arguably the most bioactive plant on the planet.
All that aside this is simply more effective since it's more dopaminergic than other cultivars, which helps solve the original problem
Jump in the discussion.
No email address required.
Why would you take SJW while on serotonergic drugs, thatβs just asking to frick your system up for a long time, like taking Uridine Monophosphate and dopaminergic drugs like adderall simultaneously will slow down your tolerance building but make it take way longer to recover.
Also, the most bio active plant psychiatrically is probably ayahuasca.
Jump in the discussion.
No email address required.
It helps treat the biggest side effect of SSRIs, I can't imagine it's that uncommon that people try the combination even if it is stupid
Jump in the discussion.
No email address required.
More options
Context
Your comment has been automatically identified as hate speech with the following parameters:
{ "toxicity": 0.9654591679573059, "severe_toxicity": 0.03924825042486191, "obscene": 0.903327465057373, "threat": 0.0026937988586723804, "insult": 0.5559346675872803, "identity_attack": 0.015792444348335266 }I am a bot, and this action was performed automatically. Please contact the moderators of /h/AgainstHateHoles if you have any questions or concerns.
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
Your comment has been automatically identified as hate speech with the following parameters:
{ "toxicity": 0.910944402217865, "severe_toxicity": 0.022500263527035713, "obscene": 0.799743115901947, "threat": 0.0018917991546913981, "insult": 0.7140282392501831, "identity_attack": 0.017601149156689644 }I am a bot, and this action was performed automatically. Please contact the moderators of /h/AgainstHateHoles if you have any questions or concerns.
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
Your comment has been automatically identified as hate speech with the following parameters:
{ "toxicity": 0.9612774848937988, "severe_toxicity": 0.04732638597488403, "obscene": 0.861544668674469, "threat": 0.004833912942558527, "insult": 0.8001747727394104, "identity_attack": 0.05690842494368553 }I am a bot, and this action was performed automatically. Please contact the moderators of /h/AgainstHateHoles if you have any questions or concerns.
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
since when did people start snorting adderall? I remember my mandated college drug awareness course saying that injecting adderall was βpopularβ, Never seen anyone do it tho.
Jump in the discussion.
No email address required.
People have been snorting it for a long time but thatβs a waste itβs best just eaten in large quantities
Jump in the discussion.
No email address required.
When i was on the extended releases i found the best was to pour some crystals in my mouth and chew
Jump in the discussion.
No email address required.
More options
Context
More options
Context
The quick releases are similar enough to other snortables that pillheads were doing that shit on instinct like immediately lol.
Got my first prescription and the first thing my cokeheaded friend says is βbro i bet these are stronger if we snort themβ
Jump in the discussion.
No email address required.
Jump in the discussion.
No email address required.
Your comment has been automatically identified as hate speech with the following parameters:
{ "toxicity": 0.938045084476471, "severe_toxicity": 0.02105018123984337, "obscene": 0.7688921093940735, "threat": 0.0015859984559938312, "insult": 0.805008053779602, "identity_attack": 0.012775878421962261 }I am a bot, and this action was performed automatically. Please contact the moderators of /h/AgainstHateHoles if you have any questions or concerns.
Jump in the discussion.
No email address required.
More options
Context
Whoaaaa
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
More options
Context
More options
Context
This neighbor doing alchemy in Elder Scrolls Oblivion and called it science
Jump in the discussion.
No email address required.
Upregulates 5ht1a postsynaptic receptors &
1 receptors & striatal dopamine
Jump in the discussion.
No email address required.
Yup, commonly taken after abusing MDA/MDMA
Jump in the discussion.
No email address required.
More options
Context
More options
Context
That fricking shit negatively interacts with everything
Jump in the discussion.
No email address required.
Aside from serotonin syndrome (which won't happen if you're not on another serotonergic drug or just take way too darn much) its problem is that it makes you metabolize other drugs so fricking fast they stop working. Off the top of my head I know it turns birth control pills into a placebo, and cyclosporine. It's also recommended to stop taking it for a week or two if you know you're going under anesthesia though I've not found much evidence to really back up that contraindication. Not that it would kill you, just jack up the required dose of anesthetic.
Which is to say you need to be thorough in your own research and careful about taking random bioactive pills without checking for interactions. Being an herb doesn't mean it's safe for the same reason that doesn't mean it's ineffective, though the reason I recommend this very specific ludicrously-priced brand is that it's seemingly the only one on the fricking planet that's standardized to a low hyperforin content, which is the chemical that causes most of the bad interactions. Thankfully the side-effects in isolation are almost literally nothing.
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
These things are even more of a meme than SSRIs
Jump in the discussion.
No email address required.
I'm not about to explain a multiaxial etiology on my phone, but cope. Definitely a meme that something proven to upregulate 5ht1a postsynaptic receptors might improve SSRI side effects
Jump in the discussion.
No email address required.
Jump in the discussion.
No email address required.
Can you tell me what a 5ht1a postsynaptic receptor does? I don't care if anybody believe it, I'm just tryna help point other people suffering like I used to in the direction of what helped, and there's very solid neuroscience behind it
Jump in the discussion.
No email address required.
Jump in the discussion.
No email address required.
More options
Context
Then why not just link to a single peer-reviewed study that even remotely supports your schizopothesis.
Jump in the discussion.
No email address required.
here I can link you to hundreds! https://scholar.google.com/scholar?hl=en&as_sdt=0%2C1&q=st+john%27s+wort+5ht1a+upregulation&btnG=
https://www.sciencedirect.com/science/article/pii/S0166432808007171?casa_token=NjjqvkM14zMAAAAA:apDyW4uVX5JWeIWQU1-zIY804xvnpScyyvOUVe70NQsHDM-c9tZBVWVA-e767AYJuQGlXofF
https://www.nature.com/articles/4000557.pdf?origin=ppub
https://journals.sagepub.com/doi/pdf/10.1177/026988110101500109?casa_token=uSmksWjPfzoAAAAA%3AVT_hIYEXqdfZhwKSOrr6E1r1mSx-kPO35dpJyNmx8MhNFLBewMq2lhXlP_HGAn49_8YZifkiwHY&
Here's one about the specific cultivar I recommended! https://pubmed.ncbi.nlm.nih.gov/11518078/
And testimonies from thousands of other people https://www.google.com/search?q=st+john%27s+wort+pssd&oq=st+john%27s+wort+pssd
Isn't it neat that you can find that stuff in like 5 seconds? What a time to be alive! It's been extensively studied for decades and used for this exact purpose by tens of thousands of men. Now quit being a lazy brainlet and don't make me do this emotional labor for you again.
Jump in the discussion.
No email address required.
Based educatedcel
Jump in the discussion.
No email address required.
I mean I get the reaction, 99.99999% of herbal "medicine" is snake oil and I was extremely skeptical too. I didn't even really believe it either for weeks after it started to actually work
Which is specifically why I recommend this brand that costs ten times what you could grab at CVS, because those are just whatever the frick happened to be growing whilst this is studied produced and regulated as an actual medicine
Jump in the discussion.
No email address required.
More options
Context
More options
Context
Thanks for doing all the work for me nerd. I was kinda interested.
Jump in the discussion.
No email address required.
More options
Context
7 =/= 100
Jump in the discussion.
No email address required.
The first link has 420 papers (dude weed lmao)
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
More options
Context
More options
Context
More options
Context
More options
Context
Trust the indigenous science bigot
Jump in the discussion.
No email address required.
"Listen up, you White peepeesucker, many moons of research and peer reviewed studies prove that smoking my ancestors testicles will heal the forest."
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
can i have a happy life without pumping myself full of non essential pharmaceuticals?
Jump in the discussion.
No email address required.
You specifically? No.
Jump in the discussion.
No email address required.
Jump in the discussion.
No email address required.
More options
Context
More options
Context
Jump in the discussion.
No email address required.
More options
Context
More options
Context
Do probiotics have any evidence of positively effecting the gut microbiome? I know kombucha has literally 0 evidence of positive effects, yet its sold fricking everywhere.
Jump in the discussion.
No email address required.
Neighbor get some actual lactobacillus not hippy dippy mayofoid tea. We're specifically trying to treat SIBO. I like nature's bounty probio 10
Jump in the discussion.
No email address required.
Im not r-slurred. I donβt drink kombucha, it doesnβt even taste good. Are there any studies about ingesting lactobacillus positively affecting the microbiome though? I feel like mfers need to stop drinking 4 days a week and thatβd help more.
Jump in the discussion.
No email address required.
There isnβt any evidence that simply consuming live bacteria is enough to have it effect on gut flora. I looked into this a while ago because I loved drinking Yakult and wanted to know if it was actually good for me or just sugar water. I still drink it but as a treat and not a every day thing now.
The issue is just a matter of the stomach being good at itβs job (killing everything with acid) and the total amount of bacteria consumed being negligible compared to the amount of bacteria that already lives in you.
Jump in the discussion.
No email address required.
You gotta boof it. So says the science
Jump in the discussion.
No email address required.
Fecal transplants niqqa
Jump in the discussion.
No email address required.
shooting streams of yakult from your butthole after an enema sounds way hotter tho
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
Yes this was my point. Also yakult is great.
Jump in the discussion.
No email address required.
Yakult is sweeter than coke
Jump in the discussion.
No email address required.
More options
Context
More options
Context
There are tons of drugs that have enteric coatings, though I don't know if I've seen any probiotics that do.
Jump in the discussion.
No email address required.
More options
Context
As someone with GI issues that stuff like Yakult and other probiotics have never helped me. Doesn't mean they don't work, could just be that my GI problems aren't necessarily a gut flora issue
Jump in the discussion.
No email address required.
If it were that easy to directly effect gut flora we wouldn't need fecal transplants. Going through the back alley makes more sense than braving the pit of acid. Yogurt is still yummy and nutritious though
Jump in the discussion.
No email address required.
As someone with some extra serious GI issues involving diarrhea+ visible bleeding they actually help a lot but it's a "when you're already fricked" or "starting to feel it's gonna get bad" kinda thing, not for when you're healthy
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
Jump in the discussion.
No email address required.
More options
Context
More options
Context
Counterpoint, lactobacillus cultures have been shown to grow testicles in mice and anecdotally work in humans too. Happy balls = happy life
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084877
Jump in the discussion.
No email address required.
More options
Context
Just start fermenting some veggies. Some fermented cabbage is awesome on sandwiches and is full of lactobacillus.
Jump in the discussion.
No email address required.
I already make spicy kimchi with carrots, daikon, and green onions.
Jump in the discussion.
No email address required.
Then you good. That has more lactobacillus than any supplement you're going to take.
Jump in the discussion.
No email address required.
Whatβs your address, let me ship you some kimchi!
Jump in the discussion.
No email address required.
Can we just have your recipe?
Jump in the discussion.
No email address required.
More options
Context
Darn, I've never been so tempted before. Is this how grooming starts?
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
More options
Context
More options
Context
It's been shown to be as effective as antibiotics for curing SIBO
Jump in the discussion.
No email address required.
Does it cure SUGMA?
Jump in the discussion.
No email address required.
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
Ginger kobucha is great when you are hungover or sick, thatβs all I got
Jump in the discussion.
No email address required.
More options
Context
You have to shove it up your butt
Jump in the discussion.
No email address required.
Your comment has been automatically identified as hate speech with the following parameters:
{ "toxicity": 0.993409276008606, "severe_toxicity": 0.0891348272562027, "obscene": 0.9552480578422546, "threat": 0.0031989403069019318, "insult": 0.6868881583213806, "identity_attack": 0.003485273802652955 }I am a bot, and this action was performed automatically. Please contact the moderators of /h/AgainstHateHoles if you have any questions or concerns.
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
More options
Context
I don't know what to believe anymore. Apparently a lot of vitamins in pill form aren't even metabolized by your body properly and may be a waste. Not all of them but some of them
Jump in the discussion.
No email address required.
Yup this is true, not every form of a molecule is bioavailable.
Jump in the discussion.
No email address required.
More options
Context
In general I take vitamins more as a way to help supplement anything youighy have missed from your food so you don't develop a deficiency than as any boost to health. It's useful for example when your stomach is fricked and you can only handle some crackers
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
St John's Wort always makes me think of this funny erowid submission about a lawyer who shits himself on it
Jump in the discussion.
No email address required.
More options
Context
You're making it sound way too complicated. He just has to balance his chakra.
Jump in the discussion.
No email address required.
More options
Context
did any of you research turn up anything on haloperidol? I'm on a very low dose and just hoping I don't get the serve reactions.
Jump in the discussion.
No email address required.
Never heard of it, nope. But if there's a serious risk of reactions I'd look into safer alternatives first. If you're not on anything serotonergic anymore I think that link is the best first-line suggestion.
Jump in the discussion.
No email address required.
good to know thanks
Jump in the discussion.
No email address required.
Just look into interactions with anything else you take, since it boosts metabolism of some drugs to the point that they become ineffective.
Jump in the discussion.
No email address required.
I was on a shit ton of meds before (meds for med's side effects...) and now I'm just on this low dose of haldol / haloperidol with OTC stuff.
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
more a risk of non-reactions... look up the word
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
bullshit
Jump in the discussion.
No email address required.
https://rdrama.net/post/87688/marseychemistmarseydoomerstudy-confirms-the-chemical-imbalance-is/2356049?context=8#context
Jump in the discussion.
No email address required.
there were thousands of studies on priming and chinese traditional medcine and ayurveda and ESP. tens of thousands on how fat causese heart disease. science is hard. a lot of science is wrong.
Jump in the discussion.
No email address required.
Definitely, but bottom-level neuroscience (what drugs have what effects on what transmitters/receptors) is a rock solid science. I don't trust a dozen studies saying what it can treat, but a hundred studies saying it impacts a specific receptor is effectively gospel, and more than anything it worked for me like night-and-day after a dozen other things had zero effect
Jump in the discussion.
No email address required.
profoundly confused. low level neuroscience has a lot of hard science, but we have no idea what any of those 'specific receeptor effects' mean in relation to more complex / larger scale relations. We know that SSRIs do all sorts of things at all sorts of receptosr, and same for all the other drugs, but have a bunch of very bad gusses for why that causes any observable dfferences in experience
more importantly, all depressed people are so because their position in and relation to modern society is based on a large stack of deceptons and fake images. they should be depressedand * should* want out, and trying to chemically fix that is just forcing yourself to forget what you've lost
Jump in the discussion.
No email address required.
this isn't about depression, this is about how we know that pumping up 5ht1a receptors makes rats c*m instantly, discrete physiological effects rather than convoluted psychological mumbo jumbo
Jump in the discussion.
No email address required.
More options
Context
More options
Context
More options
Context
More options
Context
More options
Context
More options
Context
More options
Context